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Very common side effects (affecting more than 1 in 10 people) include: Nausea — often most pronounced when initiating treatment or increasing the dose Diarrhoea — may be transient and typically improves with continued use Decreased appetite — a therapeutic effect but may lead to inadequate nutrition if extreme Common side effects (affecting up to 1 in 10 people) include: Vomiting — can contribute to dehydration if severe or persistent Constipation — may occur as part of gastrointestinal effects Abdominal pain or discomfort — usually mild and self-limiting Dyspepsia (indigestion) Fatigue — may relate to reduced caloric intake or metabolic changes Injection site reactions — redness, itching, or swelling at the injection site Hypoglycaemia — particularly when Mounjaro is used in combination with insulin or sulfonylureas [1] [19] To minimise gastrointestinal side effects, the SmPC recommends starting at the lowest dose (2.5 mg weekly) and gradually titrating upwards every four weeks